Angina, plaque and your oxidation path

Oxidised cholesterol is connected to low levels of glutathione, your body's most powerful antioxidant and detoxifier, and degenerative disease, particularly age-related diseases...

The data for this article comes from a report in Circulation: Journal of the American Heart Association, which says that oxidation is a marker for arterial plaque buildup. You can avoid most of that oxidation and the many diseases that are associated with it by ensuring your glutathione is up to snuff and by eliminating the unsaturated (pourable) oils from your diet. They are chock-full of free radicals, and polyunsaturated oils (Fish, Flax, Udo's, Soy, Corn, Canola, Sesame order, highest first) particularly have an extremely high lipid peroxidation index; that is, they rancidify quickly on the shelf, in your brain, and in your arteries.

Unsaturated, especially polyunsaturated oils, need low density lipoprotein (LDL) cholesterol to move them around, and the enormous load of free radicals presented by these oils oxidizes the LDL cholesterol and causes atherosclerosis, the narrowing of the arteries caused by free radical damage and plaques on the inner lining.

Saturated fats can not cause a problem in arterial plaques; in fact plaque has been analysed to contain up to 76% oxidized polyunsaturated oils and only 20-something percent of cholesterol that was trapped in the matrix. 

In the first study of its kind, researchers have found that blood levels of the oxidized form of LDL are directly related to the severity of heart disease. In the two-part study, Japanese researchers also found that oxidized LDL was higher in the plaques of individuals with unstable angina than those with stable angina. Oxidized LDL (ox-LDL) is a form of LDL that has combined with oxygen. It is considered more dangerous than LDL because it promotes clogging of blood vessels. Stable angina is chest pain that occurs during exertion. People with unstable angina experience chest pain even while at rest.

It is accepted that inflammation within the plaque plays a key role in destabilizing the lesions, which leads to coronary events such as heart attacks. Our findings not only support this concept, but suggest a pivotal role of oxidized LDL in this process. says study author Makiko Ueda, M.D., professor of pathology, Osaka City University Medical School in Japan.

Researchers found the more serious the condition, the higher the oxidized LDL. The researchers said the observation strongly suggests that the amount of oxidized LDL in circulating plasma could serve as a marker for cardiovascular events.

For the second part of the study they analyzed sections of coronary arteries from 10 individuals with stable and 23 with unstable angina. The sections were taken directly from the area believed to have caused the blockage responsible for the chest pain, and found the "study of atherectomy specimens clearly demonstrates that oxidized LDL is higher in the arterial plaque of patients with unstable angina compared to those with stable angina." 

Sotirios Tsimikas, M.D., assistant professor of medicine, division of cardiology, University of California at San Diego, says this research is unique because it looks at different groups of patients using the same LDL measurements. The levels of oxidized LDL circulating in the blood correlate well with the severity of disease, says Tsimikas. The sicker the patient, the higher the levels of circulating oxidized LDL, indicating that it is a marker of atherosclerotic plaques.

I've been beating this drum for awhile now because cardiovascular incidents are the biggest killers in our population, and the vast majority of these incidents are completely preventable simply by changing the oils you eat and getting modest excercise.

None of the peer-reviewed research data ever supported the Heart and Stroke Foundation's propaganda for unsaturated oils and against saturated fats, the healthiest oils in your diet. And you DONATE to those guys?